BISTRO Pulse Sequence

The CMRR software downloads have migrated to a new site!

If you have not visited this page since Dec 26, 2025, you will need to reset your password. Your username is the email address that you used to sign the MTA license agreement.

Please be aware that while Siemens C2P agreements are for the specific scanner+institution, the MTA agreement to download sequences on this site are for an individual. If your institution needs to change or add additional authorized people to download sequences, each person will need to sign the MTA agreement and then CMRR will create an account on this site.

This sequence package includes the executable BISTRO-FID pulse sequence on Siemens MRI scanner platform. BISTRO (B1-insensitive train to obliterate signal) sequence segment is the magnet field B1-insensitive, frequency-selective saturation pulse train with varied low RF power for use of water suppression and narrow band saturation. BISTRO is applied prior to the single-pulse-acquire pulse sequence for performing the magnetization transfer MRS experiment.

License

Obtaining a license

The available supported software versions are listed below. If you are interested in obtaining these sequences, please follow this process to obtain a CMRR license:

  1. Obtain authorization from your Siemens Regional Collaboration Manager for the specific software you would like to license. 
    1. Contact your Siemens Regional Collaboration Manager for authorization. Please ask them to use the following text in the agreement: "developed by Dr. Wei Chen and colleagues (“DEVELOPER”), employees of the University of Minnesota." If you are experiencing any delays working with your Siemens Regional Collaboration Manager please contact Colin Giambrone (colin.giambrone@siemens-healthineers.com). 
    2. Send the completed authorization form to Wei Chen
  2. Select the license from the OTC website and complete the license agreement.
  3. CMRR will send you your account information and instructions for downloading the software.

Please note that the entire licensing process may take up to two weeks to process.

Once you have executed a C2P agreement and have been given an access password, the sequence binaries can be downloaded here by selecting the desired release number.

Note: The C2P agreement in step 1 applies to the institution (scanner), whereas the MTA agreement in step 2 applies to an individual. If someone else at your institution has historically been the download contact for sequences and you would also like download access, please sign the MTA agreement and CMRR will create a download account for you.

Citation

If you publish or present results obtained using the software or sequences in this package, please acknowledge the researchers who developed the sequences using the following language:

Chen W, Luo Y, Merkle H, Zhu X-H, Adriany G, Garwood M, Ugurbil K. Low-power, B1 -insensitive, frequency-selective saturation pulse for use of water suppression and saturation transfer in NMR. In: SMR, 3rd Annual Meeting; 1995; Nice, France. p. 1016.

Lei H, et al. Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy. Proc Natl Acad Sci U S A. 2003; 100:14409-14. doi: 10.1073/pnas.2332656100

de Graaf RA, et al. B1-insensitive, single-shot localization and water suppression. J Magn Reson B. 1996; 113:35-45. doi: 10.1006/jmrb.1996.0152

Contact

If you have noticed a bug or have a request for a new feature in a future release, please contact

Wei Chen. Be sure to include the sequence variant and the model of scanner you are using in the problem description.

Download

Please contact Wei Chen to obtain access to this software package.


References

  1. Chen W, Luo Y, Merkle H, Zhu X-H, Adriany G, Garwood M, Ugurbil K. Low-power, B1 -insensitive, frequency-selective saturation pulse for use of water suppression and saturation transfer in NMR. In: SMR, 3rd Annual Meeting; 1995; Nice, France. p. 1016.

  2. Lei H, et al. Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy. Proc Natl Acad Sci U S A. 2003; 100:14409-14. doi: 10.1073/pnas.2332656100

  3. de Graaf RA, et al. B1-insensitive, single-shot localization and water suppression. J Magn Reson B. 1996; 113:35-45. doi: 10.1006/jmrb.1996.0152

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